•M.S. from National Center for Biological Sciences, Bangalore, India
•Ph.D from Carnegie Mellon University, Pittsburgh PA
•Postdoctoral research at the UCSF Diabetes Center, San Francisco CA
Research project :
•Adult β-cell fate specification and function in disease models
The Vhlh gene codes for the von-Hippel Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. Elimination of Vhlh in adult mouse pancreatic β-cells leads to a severe defect in glucose homeostasis, with impaired insulin secretion upon glucose stimulation (Puri et al. Diabetes 2009). We are currently exploring the mechanisms underlying the changes that impact β-cell function in this “genetic hypoxia” model.